Ultrapure Ergothioneine, extracted using advanced supercritical fluid technology, is a naturally occurring thiol compound that functions as a highly efficient, mitochondria-targeted antioxidant. Recognised for its exceptional cellular defence capabilities, Ergothioneine is transported into cells via the exclusive OCTN-1 transporter, where it accumulates in high-energy-demanding tissues such as the ovaries, uterus, and brain.

For women, this compound plays a pivotal role in protecting ovarian cells from oxidative stress—a key contributor to diminished ovarian reserve, hormonal imbalance, and early onset reproductive ageing. By neutralising reactive oxygen species (ROS) within ovarian mitochondria, Ergothioneine supports the structural integrity of oocytes and enhances follicular health, which is essential for hormonal regulation, fertility, and menstrual cycle regularity. It also assists in relieving symptoms of dysmenorrhoea, premenstrual breast tenderness, and mood fluctuations associated with hormonal imbalances.

Clinical studies have demonstrated that Ultrapure Ergothioneine increases endogenous antioxidant enzyme activity (via KEAP1–NRF2 activation), reduces inflammatory markers, and supports mitochondrial energy metabolism—factors that collectively improve uterine and vaginal tissue resilience. This contributes to the alleviation of menopausal symptoms such as vaginal dryness, hot flashes, and disrupted flora, while promoting healthy vaginal pH and immune function.

Additionally, Ergothioneine has been shown to improve skin texture, boost collagen production, and reduce the appearance of fine lines, offering added benefits to women seeking anti-ageing and photoprotection solutions. With superior bioavailability and stability, especially in enteric-coated and nanoencapsulated delivery formats, Ultrapure Ergothioneine is a leading-edge ingredient for integrative female wellness—supporting hormonal harmony, reproductive vitality, and graceful ageing.

Sources：
Hseu, Y.-C., Lo, H.-W., Korivi, M., Tsai, Y.-C., Tang, M.-J., & Yang, H.-L. (2015). Dermato-protective properties of ergothioneine through induction of Nrf2/ARE-mediated antioxidant genes in UVA-irradiated human keratinocytes. Free Radical Biology & Medicine, 86, 102–117. https://doi.org/10.1016/j.freeradbiomed.2015.05.026 

Cheah, I. K., & Halliwell, B. (2012). Ergothioneine; antioxidant potential, physiological function and role in disease. Biochimica et Biophysica Acta, 1822(5), 784–793. https://doi.org/10.1016/j.bbadis.2011.09.017 

Tang, M.-J., & Yang, H.-L. (2023). Safe and effective antioxidant: The biological mechanism and potential pathways of ergothioneine in the skin. Molecules, 28(4), 1648. https://doi.org/10.3390/molecules28041648 

Paiva, C., et al. (2021). Antioxidant effect of ergothioneine on in vitro maturation of porcine oocytes. Animal Reproduction, 18(2), e20210048. https://doi.org/10.1590/1984-3143-ar2021-0048 

Yang, X., et al. (2021). The role of oxidative stress and natural antioxidants in ovarian aging. Frontiers in Endocrinology, 11, 579794. https://doi.org/10.3389/fendo.2020.579794